Huwandu hukuru hwemabhafa hunodiwa mukudzika kwemvura yekuchenesa maitiro ebiopharmaceuticals. Kurongeka uye kuberekana kwemabhafa kune simba guru pakugadzirisa mapuroteni. Iyo yepamhepo dilution uye online dosing system inogona kusanganisa dzakasiyana-siyana-chikamu mabhafa. Doro raamai nerinodhaka zvinosanganiswa pamhepo kuti vawane mhinduro yekunangwa. Chigadzirwa chacho chakavakirwa paruzivo rwesainzi, uye hunhu hunobva kupfungwa yekugadzira (QbD). Kuburikidza neiyo chaiyo-nguva yepamhepo (Chaiyo nenguva) yekutarisa uye kutonga kweaviri emakemikari zviratidzo, akakosha emhando hunhu (CQA) yechigadzirwa (CQA), pH uye conductivity panguva yekugadzira maitiro, Ita shuwa kupa mabuffers akagadzikana uye mayunifomu. kunaka kwemaitiro ekudzika kubatsira biopharmaceutical makambani 'parameter kuburitsa zvinangwa. Iyo yechinyakare yegadziriro yemvura yekugadzirira inoda nhamba yakakura yematangi uye yakakura vhoriyamu. IVEN inounza vatengi ruzivo rutsva rwehunyanzvi, kudzikisa tsoka yeiyo buffer dosing mudanho rekucheneswa, uye kudzikisa kusati kwaita mari uye mushure mekugadzira uye mutengo wekushanda. , Kuvandudza mashandiro ekugadzira, simbisa iyo yakakosha process paramita (CPP) yebuffer uye traceability yayo, uye pakupedzisira inovandudza mhando yemishonga.